Liver Cancer

How artificial intelligence is transforming Liver Cancer detection, diagnosis, and treatment.

90 Papers Open Access

Showing all 90 papers

Cited by 2265
Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma.

Cell, 2017

Open Access
Cited by 2201
The Liver Tumor Segmentation Benchmark (LiTS).

Med Image Anal, 2023

Open Access
Cited by 1379
Liver Cancer Cell of Origin, Molecular Class, and Effects on Patient Prognosis.

Gastroenterology, 2017

Open Access
Cited by 1237
Deep Learning-Based Multi-Omics Integration Robustly Predicts Survival in Liver Cancer.

Clin Cancer Res, 2018

Open Access
Cited by 1010
Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma.

Cancer Discov, 2017

Open Access
Cited by 811
Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles.

Cell Rep, 2017

Open Access
Cited by 787
Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas.

Nat Genet, 2013

Open Access
Cited by 724
Assessing the performance of ChatGPT in answering questions regarding cirrhosis and hepatocellular carcinoma.

Clin Mol Hepatol, 2023

Open Access
Cited by 720
Single-cell triple omics sequencing reveals genetic, epigenetic, and transcriptomic heterogeneity in hepatocellular carcinomas.

Cell Res, 2016

Open Access
Cited by 670
Integrative molecular analysis of intrahepatic cholangiocarcinoma reveals 2 classes that have different outcomes.

Gastroenterology, 2013

Open Access
Cited by 581
Biomarkers in Hepatocellular Carcinoma: Diagnosis, Prognosis and Treatment Response Assessment.

Cells, 2020

Open Access
Cited by 567
Noninvasive detection of cancer-associated genome-wide hypomethylation and copy number aberrations by plasma DNA bisulfite sequencing.

Proc Natl Acad Sci U S A, 2013

Open Access
Cited by 538
Identification of a therapeutic strategy targeting amplified FGF19 in liver cancer by Oncogenomic screening.

Cancer Cell, 2011

Open Access
Cited by 494
The tumor microenvironment in hepatocellular carcinoma: current status and therapeutic targets.

Semin Cancer Biol, 2011

Open Access
Cited by 491
Combining clinical, pathology, and gene expression data to predict recurrence of hepatocellular carcinoma.

Gastroenterology, 2011

Open Access
Cited by 474
The biology of Hepatocellular carcinoma: implications for genomic and immune therapies.

Mol Cancer, 2017

Open Access
Cited by 473
Identification of anticancer drugs for hepatocellular carcinoma through personalized genome-scale metabolic modeling.

Mol Syst Biol, 2014

Open Access
Cited by 459
DNA methylation-based prognosis and epidrivers in hepatocellular carcinoma.

Hepatology, 2015

Open Access
Cited by 442
Extremely high genetic diversity in a single tumor points to prevalence of non-Darwinian cell evolution.

Proc Natl Acad Sci U S A, 2015

Open Access
Cited by 410
Deep learning for liver tumor diagnosis part I: development of a convolutional neural network classifier for multi-phasic MRI.

Eur Radiol, 2019

Open Access
Cited by 402
Identification of osteopontin as a novel marker for early hepatocellular carcinoma.

Hepatology, 2012

Open Access
Cited by 398
Recent Updates of Transarterial Chemoembolilzation in Hepatocellular Carcinoma.

Int J Mol Sci, 2020

Open Access
Cited by 397
Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma.

Hepatology, 2014

Open Access
Cited by 394
AlphaFold accelerates artificial intelligence powered drug discovery: efficient discovery of a novel CDK20 small molecule inhibitor.

Chem Sci, 2023

Open Access
Cited by 392
Notch signaling is activated in human hepatocellular carcinoma and induces tumor formation in mice.

Gastroenterology, 2012

Open Access
Cited by 382
Comprehensive analysis of spatial architecture in primary liver cancer.

Sci Adv, 2021

Open Access
Cited by 380
The long noncoding RNA lnc-EGFR stimulates T-regulatory cells differentiation thus promoting hepatocellular carcinoma immune evasion.

Nat Commun, 2017

Open Access
Cited by 380
Wnt-pathway activation in two molecular classes of hepatocellular carcinoma and experimental modulation by sorafenib.

Clin Cancer Res, 2012

Open Access
Cited by 376
p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming.

Nat Commun, 2016

Open Access
Cited by 366
Hepatocellular carcinoma: old friends and new tricks.

Exp Mol Med, 2020

Open Access
Cited by 363
The effects of hepatitis B virus integration into the genomes of hepatocellular carcinoma patients.

Genome Res, 2012

Open Access
Cited by 353
Integrated multiomic analysis reveals comprehensive tumour heterogeneity and novel immunophenotypic classification in hepatocellular carcinomas.

Gut, 2019

Open Access
Cited by 353
β-Catenin signaling in hepatocellular carcinoma.

J Clin Invest, 2022

Open Access
Cited by 347
Circular RNA circRHOT1 promotes hepatocellular carcinoma progression by initiation of NR2F6 expression.

Mol Cancer, 2019

Open Access
Cited by 347
Single-cell atlas of tumor cell evolution in response to therapy in hepatocellular carcinoma and intrahepatic cholangiocarcinoma.

J Hepatol, 2021

Open Access
Cited by 345
UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma.

Cancer Cell, 2014

Open Access
Cited by 343
In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer.

Nat Med, 2014

Open Access
Cited by 341
Identification of Four Immune Subtypes Characterized by Distinct Composition and Functions of Tumor Microenvironment in Intrahepatic Cholangiocarcinoma.

Hepatology, 2020

Open Access
Cited by 339
Machine learning algorithms outperform conventional regression models in predicting development of hepatocellular carcinoma.

Am J Gastroenterol, 2013

Open Access
Cited by 339
Molecular predictors of prevention of recurrence in HCC with sorafenib as adjuvant treatment and prognostic factors in the phase 3 STORM trial.

Gut, 2019

Open Access
Cited by 339
Recurrently deregulated lncRNAs in hepatocellular carcinoma.

Nat Commun, 2017

Open Access
Cited by 339
Targeting tumor-associated macrophages and granulocytic myeloid-derived suppressor cells augments PD-1 blockade in cholangiocarcinoma.

J Clin Invest, 2020

Open Access
Cited by 336
Artificial intelligence for the prevention and clinical management of hepatocellular carcinoma

J Hepatol, 2022

Open Access
Cited by 335
YTHDF2 reduction fuels inflammation and vascular abnormalization in hepatocellular carcinoma.

Mol Cancer, 2019

Open Access
Cited by 322
A Radiomics Nomogram for Preoperative Prediction of Microvascular Invasion in Hepatocellular Carcinoma.

Liver Cancer, 2019

Open Access
Cited by 313
Mutational signatures reveal the dynamic interplay of risk factors and cellular processes during liver tumorigenesis.

Nat Commun, 2017

Open Access
Cited by 299
Arid1a Has Context-Dependent Oncogenic and Tumor Suppressor Functions in Liver Cancer.

Cancer Cell, 2017

Open Access
Cited by 298
HCV-Induced Epigenetic Changes Associated With Liver Cancer Risk Persist After Sustained Virologic Response.

Gastroenterology, 2019

Open Access
Cited by 295
Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes.

Cancer Cell, 2019

Open Access
Cited by 289
Genome-wide methylation analysis and epigenetic unmasking identify tumor suppressor genes in hepatocellular carcinoma.

Gastroenterology, 2013

Open Access
Cited by 288
A circRNA-miRNA-mRNA network identification for exploring underlying pathogenesis and therapy strategy of hepatocellular carcinoma.

J Transl Med, 2018

Open Access
Cited by 285
Accurate quantification of circular RNAs identifies extensive circular isoform switching events.

Nat Commun, 2020

Open Access
Cited by 284
HCCDB: A Database of Hepatocellular Carcinoma Expression Atlas.

Genomics Proteomics Bioinformatics, 2018

Open Access
Cited by 278
MicroRNA-145 Modulates N(6)-Methyladenosine Levels by Targeting the 3'-Untranslated mRNA Region of the N(6)-Methyladenosine Binding YTH Domain Family 2 Protein.

J Biol Chem, 2017

Open Access
Cited by 269
Prognostic gene expression signature for patients with hepatitis C-related early-stage cirrhosis.

Gastroenterology, 2013

Open Access
Cited by 266
MicroRNA-based classification of hepatocellular carcinoma and oncogenic role of miR-517a.

Gastroenterology, 2011

Open Access
Cited by 264
Inflamed and non-inflamed classes of HCC: a revised immunogenomic classification.

Gut, 2023

Open Access
Cited by 255
Delineation of an immunosuppressive gradient in hepatocellular carcinoma using high-dimensional proteomic and transcriptomic analyses.

Proc Natl Acad Sci U S A, 2017

Open Access
Cited by 253
Dynamic network biomarker indicates pulmonary metastasis at the tipping point of hepatocellular carcinoma.

Nat Commun, 2018

Open Access
Cited by 251
Targeting glutaminase 1 attenuates stemness properties in hepatocellular carcinoma by increasing reactive oxygen species and suppressing Wnt/beta-catenin pathway.

EBioMedicine, 2019

Open Access
Cited by 250
Comprehensive molecular and immunological characterization of hepatocellular carcinoma.

EBioMedicine, 2019

Open Access
Cited by 243
GOLM1 Modulates EGFR/RTK Cell-Surface Recycling to Drive Hepatocellular Carcinoma Metastasis.

Cancer Cell, 2016

Open Access
Cited by 241
Tissue metabolomics of hepatocellular carcinoma: tumor energy metabolism and the role of transcriptomic classification.

Hepatology, 2013

Open Access
Cited by 239
Multi-scale and multi-parametric radiomics of gadoxetate disodium-enhanced MRI predicts microvascular invasion and outcome in patients with solitary hepatocellular carcinoma ≤ 5 cm.

Eur Radiol, 2021

Open Access
Cited by 236
HIF-1α promoted vasculogenic mimicry formation in hepatocellular carcinoma through LOXL2 up-regulation in hypoxic tumor microenvironment.

J Exp Clin Cancer Res, 2017

Open Access
Cited by 217
Tumor-adjacent tissue co-expression profile analysis reveals pro-oncogenic ribosomal gene signature for prognosis of resectable hepatocellular carcinoma.

Mol Oncol, 2018

Open Access
Cited by 113
Deep learning with convolutional neural networks for identification of liver masses and hepatocellular carcinoma: A systematic review

World J Gastrointest Oncol, 2019

Open Access
Cited by 109
Convergence of nanotechnology and artificial intelligence in the fight against liver cancer: a comprehensive review

Discov Oncol, 2025

Open Access
Cited by 103
The power of deep learning in simplifying feature selection for hepatocellular carcinoma: a review

BMC Med Inform Decis Mak, 2024

Open Access
Cited by 88
Detection of Hepatocellular Carcinoma in Contrast-Enhanced Magnetic Resonance Imaging Using Deep Learning Classifier: A Multi-Center Retrospective Study

Sci Rep, 2020

Open Access
Cited by 84
Application of artificial intelligence in the diagnosis and treatment of hepatocellular carcinoma: A review

World J Gastroenterol, 2020

Open Access
Cited by 56
Deep learning in hepatocellular carcinoma: Current status and future perspectives

World J Hepatol, 2021

Open Access
Cited by 34
Clinical Applications of Artificial Intelligence (AI) in Human Cancer: Is It Time to Update the Diagnostic and Predictive Models in Managing Hepatocellular Carcinoma (HCC)?

Diagnostics (Basel), 2025

Open Access
Cited by 34
Deep Learning for the Pathologic Diagnosis of Hepatocellular Carcinoma Cholangiocarcinoma and Metastatic Colorectal Cancer

Cancers (Basel), 2023

Open Access
Cited by 28
A CT-Based Deep Learning-Driven Tool for Automatic Liver Tumor Detection and Delineation in Patients with Cancer

Cell Rep Med, 2025

Open Access
Cited by 27
Artificial Intelligence in the Diagnosis of Hepatocellular Carcinoma: A Systematic Review

J Clin Med, 2022

Open Access
Cited by 25
Development of a Deep Learning Model to Assist With Diagnosis of Hepatocellular Carcinoma

Front Oncol, 2021

Open Access
Cited by 24
Quantitative analysis of artificial intelligence on liver cancer: A bibliometric analysis

Front Oncol, 2023

Open Access
Cited by 20
Deep Learning-Based Accurate Diagnosis and Quantitative Evaluation of Microvascular Invasion in Hepatocellular Carcinoma on Whole-Slide Histopathology Images

Cancer Med, 2024

Open Access
Cited by 14
A Novel Prognostic Score Based on Artificial Intelligence in Hepatocellular Carcinoma: A Long-Term Follow-Up Analysis

Front Oncol, 2022

Open Access
Cited by 10
Deep Learning for Hepatocellular Carcinoma Segmentation in MRI: A Systematic Review of Models Performance and Challenges

Medicine (Baltimore), 2025

Open Access
Cited by 9
An Artificial Intelligence Pipeline for Hepatocellular Carcinoma: From Data to Treatment Recommendations

Int J Gen Med, 2025

Open Access
Cited by 8
Advances and challenges in pathomics for liver cancer: From diagnosis to prognostic stratification

World J Clin Oncol, 2025

Open Access
Cited by 8
Artificial Intelligence-Driven Pathomics in Hepatocellular Carcinoma: Current Developments Challenges and Perspectives

Discov Oncol, 2025

Open Access
Cited by 7
Enhancing Ultrasonographic Detection of Hepatocellular Carcinoma with Artificial Intelligence: Current Applications Challenges and Future Directions

BMJ Open Gastroenterol, 2025

Open Access
Cited by 5
A deep learning framework for hepatocellular carcinoma diagnosis using MS1 data

Sci Rep, 2024

Open Access
Cited by 4
Automatic Real-Time Detection and Diagnosis of Liver Tumor with Ultrasound

J Hepatocell Carcinoma, 2025

Open Access
Cited by 3
Deep Learning to Enhance Diagnosis and Management of Intrahepatic Cholangiocarcinoma

Cancers (Basel), 2025

Open Access
Cited by 3
HTRecNet: A Deep Learning Study for Efficient and Accurate Diagnosis of Hepatocellular Carcinoma and Cholangiocarcinoma

Front Cell Dev Biol, 2025

Open Access
Cited by 0
A Contrast-Enhanced Ultrasound Cine-Based Deep Learning Model for Predicting Response of Advanced HCC to Systemic Therapies

Cancer Sci, 2025

Open Access