Colorectal Cancer

How artificial intelligence is transforming Colorectal Cancer detection, diagnosis, and treatment.

136 Papers Open Access

Showing all 136 papers

Cited by 873
Deep Learning Localizes and Identifies Polyps in Real Time with 96% Accuracy in Screening Colonoscopy

Gastroenterology, 2018

Open Access
Cited by 266
Interpretable survival prediction for colorectal cancer using deep learning

NPJ Digit Med, 2021

Open Access
Cited by 151
Deep Learning on Histopathological Images for Colorectal Cancer Diagnosis: A Systematic Review

Diagnostics (Basel), 2022

Open Access
Cited by 134
Application of artificial intelligence in diagnosis and treatment of colorectal cancer: A novel Prospect

Front Med (Lausanne), 2023

Open Access
Cited by 129
Prediction of Colon Cancer Stages and Survival Period with Machine Learning Approach

Cancers (Basel), 2019

Open Access
Cited by 85
Application of artificial intelligence to the diagnosis and therapy of colorectal cancer

Am J Cancer Res, 2020

Open Access
Cited by 70
Deep learning for multi-class semantic segmentation enables colorectal cancer detection and classification in digital pathology images

Sci Rep, 2023

Open Access
Cited by 63
Deep Neural Network Models for Colon Cancer Screening

Cancers (Basel), 2022

Open Access
Cited by 50
Detection of Colorectal Polyps from Colonoscopy Using Machine Learning: A Survey on Modern Techniques

Sensors (Basel), 2023

Open Access
Cited by 28
Artificial Intelligence Applications in the Treatment of Colorectal Cancer: A Narrative Review

Clin Med Insights Oncol, 2024

Open Access
Cited by 28
Artificial Intelligence in the Diagnosis of Colorectal Cancer: A Literature Review

Diagnostics (Basel), 2024

Open Access
Cited by 16
Deep Learning Empowers Endoscopic Detection and Polyps Classification: A Multiple-Hospital Study

Diagnostics (Basel), 2023

Open Access
Cited by 14
Advanced Deep Learning for Multi-Class Colorectal Cancer Histopathology: Integrating Transfer Learning and Ensemble Methods

Quant Imaging Med Surg, 2025

Open Access
Cited by 14
Deep Learning Model for Gastrointestinal Polyp Segmentation

PeerJ Comput Sci, 2025

Open Access
Cited by 13
Artificial intelligence algorithms for real-time detection of colorectal polyps during colonoscopy: a review

Am J Cancer Res, 2024

Open Access
Cited by 11
The Development of an Efficient AI-Based Classification Approach for Colorectal Cancer Response to Radiochemotherapy: Deep Learning vs Machine Learning

Sci Rep, 2025

Open Access
Cited by 11
The Use of Artificial Intelligence in Predicting Chemotherapy-Induced Toxicities in Metastatic Colorectal Cancer: A Data-Driven Approach for Personalized Oncology

Diagnostics (Basel), 2024

Open Access
Cited by 10
From Pixels to Prognosis: A Narrative Review on Artificial Intelligence's Pioneering Role in Colorectal Carcinoma Histopathology

Cureus, 2024

Open Access
Cited by 10
Use of Artificial Intelligence in the Diagnosis of Colorectal Cancer

Cureus, 2024

Open Access
Cited by 9
A Contrast-Enhanced CT-Based Deep Learning System for Preoperative Prediction of Colorectal Cancer Staging and RAS Mutation

Cancers (Basel), 2023

Open Access
Cited by 7
Real-Time Artificial Intelligence Versus Standard Colonoscopy in the Early Detection of Colorectal Cancer: A Systematic Review and Meta-Analysis

Healthcare (Basel), 2025

Open Access
Cited by 6
Deep Learning Model Applied to Real-Time Delineation of Colorectal Polyps

BMC Med Inform Decis Mak, 2025

Open Access
Cited by 5
Modernizing Colorectal Cancer Care With Artificial Intelligence: Real-Time Detection, Radiomics, and Digital Pathology

Cureus, 2025

Open Access
Cited by 3
Tumor vessel phenotype in colorectal cancer microenvironment according to age at diagnosis

Br J Cancer, 2026

Open Access
Cited by 2
Expression profiling of inhibitory immune checkpoints in colorectal cancer stem cells and their association with tumor immunity and immunotherapy biomarkers

Front Immunol, 2026

Open Access
Cited by 1
Association between Vitamin B12 Levels and Colon Cancer Survival: A Global Network Study

Cancer Res Commun, 2026

Open Access
Cited by 1
Cathepsin E drives colorectal cancer progression and immune evasion via ZNF326 ADP-ribosylation and TGF-β/SMAD activation

J Transl Med, 2026

Open Access
Cited by 1
Characterization of Computed Tomography Colonography Findings of Ulcerative Colitis-Associated Neoplasia

Inflamm Bowel Dis, 2026

Open Access
Cited by 1
Cohort-Scale Spatial Autocorrelation for Tumor Prediction in Mid-Infrared Pathology and Spatial Biomarker Discovery Using MALDI Imaging Lipidomics

Adv Sci (Weinh), 2026

Open Access
Cited by 1
Deep ensemble of multi-head attention CNNs for histopathological image-based of lung and colon cancer diagnosis

Digit Health, 2026

Open Access
Cited by 1
Diagnostic Potential of Exosomes in Colorectal Cancer: Current Advances and Future Perspectives

Molecules, 2026

Open Access
Cited by 1
Efficacy and cost-effectiveness of extending risk-stratified colorectal cancer screening: evidence from China's first province-wide program

Int J Surg, 2026

Open Access
Cited by 1
Establishing reference standards for small and diminutive colorectal polyp size: validation of caliper-based size measurement

J Can Assoc Gastroenterol, 2026

Open Access
Cited by 1
Gastrointestinal endoscopic image style transfer using EndoStyle to improve artificial intelligence prediction models

NPJ Digit Med, 2026

Open Access
Cited by 1
Molecular-Clinical Characteristics and Treatment Outcomes in 163 Metastatic Colorectal Neuroendocrine Carcinomas with a Comparison to Colorectal Adenocarcinomas

Int J Cancer, 2026

Open Access
Cited by 1
Research status and trends of deep learning in colorectal cancer (2011-2023): Bibliometric analysis and visualization

World J Gastrointest Oncol, 2025

Open Access
Cited by 1
Should we screen for colorectal cancer with biennial FIT beginning at age 45 in Canada?

J Can Assoc Gastroenterol, 2026

Open Access
Cited by 1
TGF-β/SMAD4/14-3-3σ/TFEB axis promotes mesenchymal-epithelial transition and inhibits autophagy in colorectal cancer

Cell Death Dis, 2026

Open Access
Cited by 0
A comprehensive European Colorectal Cancer Cohort dataset

Sci Data, 2026

Open Access
Cited by 0
A Machine Learning Framework for Prognostic Modeling in Stage III Colon Cancer

J Clin Med, 2026

Open Access
Cited by 0
A Multi-omics PTM Atlas Reveals Key Insights into Metabolic Reprogramming in Colorectal Cancer

Cancer Genomics Proteomics, 2026

Open Access
Cited by 0
A Multicellular 3D GelMA-Based Colorectal Cancer Model for Chemotherapeutic Responses

Macromol Biosci, 2026

Open Access
Cited by 0
A Multimodal Stool RNA, FIT, and Machine Learning Concept for the Detection of Advanced Precancerous Lesions and Colorectal Cancer

Cancer Prev Res (Phila), 2026

Open Access
Cited by 0
A risk assessment model for colon cancer and precancerous lesions based on cancer screening and external validation of the NHANES database

Front Oncol, 2026

Open Access
Cited by 0
A risk prediction model for overall and Grade C anastomotic leakage after rectal cancer surgery

Front Oncol, 2026

Open Access
Cited by 0
Accuracy of Fecal Immunochemical Tests for Detecting Advanced Colorectal Neoplasia at Surveillance Colonoscopy

Clin Transl Gastroenterol, 2026

Open Access
Cited by 0
AI-Enhanced Vibrational Capsule for Minimally Invasive Detection of Abnormal Bowel Tissue

Adv Sci (Weinh), 2026

Open Access
Cited by 0
Alcohol consumption and colorectal carcinogenesis: an exploration of the gut microbial pathway as a potential mediator

Eur J Nutr, 2026

Open Access
Cited by 0
An integrated bulk and single-cell transcriptomic analysis reveals stemness-driven immune regulation and therapeutic vulnerability in colorectal cancer

J Cancer, 2026

Open Access
Cited by 0
An m6A-programmed cell death signature predicts prognosis and identifies STK25 as a therapeutic target in colon adenocarcinoma

Oncol Lett, 2026

Open Access
Cited by 0
Antitumoral immunity induced by gel ethanol ablation to treat unresectable colorectal cancer metastases in the liver

PLoS One, 2026

Open Access
Cited by 0
APC coordinates GSK3 phosphorylation of SETD8 to suppress colorectal cancer

Cell Rep, 2026

Open Access
Cited by 0
Artificial intelligence real-time overall recognition model for total mesorectal excision

Int J Surg, 2026

Open Access
Cited by 0
Association Between Colorectal Neoplasia and Subclinical Coronary Atherosclerosis in Asymptomatic Individuals

J Korean Med Sci, 2026

Open Access
Cited by 0
Bidirectional Interactions Between Immune Regulation and the Insulin-like Growth Factor Axis in Colorectal Cancer

Int J Mol Sci, 2026

Open Access
Cited by 0
CALB2 mediates tumor progression and immune escape in colorectal cancer by shaping an inhibitory immune microenvironment

Front Immunol, 2026

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Cited by 0
Case Report: Successful endoscopic resection of a huge rectal tumor extending to the dentate line and associated with a diverticulum by endoscopic submucosal dissection

Front Med (Lausanne), 2026

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Cited by 0
Case Report: Ultrasound features of pathological complete response in middle and low rectal cancer with high microsatellite instability after neoadjuvant immunotherapy: a case series

Front Immunol, 2026

Open Access
Cited by 0
Cholesterol Reprograms Oxysterol Metabolism via the LOX1/CH25H/CYP7B1 Signaling Axis to Drive Multidrug Resistance in Colorectal Cancer

Hum Mutat, 2026

Open Access
Cited by 0
Cold-spot driven local failure after stereotactic body radiation therapy for colorectal liver metastases

Front Oncol, 2026

Open Access
Cited by 0
Colorectal cancer in ulcerative colitis: unraveling mechanisms and advancing surveillance and chemoprevention

Front Oncol, 2026

Open Access
Cited by 0
Copy number alteration fingerprint predicts the clinical response of oxaliplatin-based chemotherapy in metastatic colorectal cancer

NPJ Precis Oncol, 2026

Open Access
Cited by 0
CT-Based Radiomic Signatures Associated with Serum CEA Status in Colon Cancer

Diagnostics (Basel), 2026

Open Access
Cited by 0
Deciphering immune and cellular reprogramming during the progression from inflammatory bowel disease to colorectal cancer using multi-omics single-cell and spatial transcriptomics

J Transl Med, 2026

Open Access
Cited by 0
Development and validation of machine learning models for predicting cancer-specific survival in colorectal signet ring cell carcinoma

BMC Gastroenterol, 2026

Open Access
Cited by 0
Diagnostic CT–guided online adaptive radiotherapy for locally advanced colon cancer: a prospective implementation and feasibility study

Clin Transl Radiat Oncol, 2026

Open Access
Cited by 0
Diagnostic Performance of a Deep Learning-Based Tool for the Detection and Staging of Rectal Cancers on Endoscopic Ultrasound: Prospective Study

Diagnostics (Basel), 2026

Open Access
Cited by 0
Discovery of Biomarkers Related to Colorectal Cancer by Systematic Proteomics Analysis and Experimental Procedures

Iran J Med Sci, 2026

Open Access
Cited by 0
Dual targeting of topoisomerase I and DNA G-quadruplexes enhances senescence and chemosensitivity in colorectal cancer

Commun Biol, 2026

Open Access
Cited by 0
Endorectal Ultrasound Versus MRI for Lower and Middle Rectal Cancer Staging in Upfront Surgery: A Comparative Study

J Clin Med, 2026

Open Access
Cited by 0
Enhanced mRNA Expression of Colonic IL-6 in Cronkhite-Canada Syndrome Bearing Colorectal Cancer

In Vivo, 2026

Open Access
Cited by 0
Enhanced recovery after surgery compliance and postoperative recovery in elderly colorectal cancer patients: a propensity score matched cohort study

Front Oncol, 2026

Open Access
Cited by 0
Examining the gene network and prognostic biomarkers in the onset of colorectal cancer in stool samples using machine learning

Discov Oncol, 2026

Open Access
Cited by 0
Exploring the Relationship Between Colitis-Associated Cancer and Lipid Metabolism Reprogramming from the Perspective of Inflammation-Cancer Transformation

J Inflamm Res, 2026

Open Access
Cited by 0
FAP-Anchored Retinoic Acid Nanoparticles for Stromal Reprogramming and Enhanced Intratumoral Oxaliplatin Delivery in Fibrotic Colorectal Tumours

Biosensors (Basel), 2026

Open Access
Cited by 0
First Japanese Experience of Robotic-Assisted Low Anterior Resection Using the da Vinci 5: Incorporating Force Feedback and Case Insights in Rectal Cancer Surgery

Surg Case Rep, 2026

Open Access
Cited by 0
Folate promotes colorectal cancer progression by impairing CD8+ T cell function and recruitment via SLC19A1/p-AKT/NOTCH1 axis and CCL5 downregulation

J Transl Med, 2026

Open Access
Cited by 0
HIT101308137 and HIT104293658 nominate dual target chemotypes for PTPN1 and PTPN2 with preliminary selectivity in colorectal cancer cells

Front Chem, 2026

Open Access
Cited by 0
Hypoxic CAF studies unveil PTHrP-vitamin D-RAS axis as pivotal in the CAF

Oncol Rep, 2026

Open Access
Cited by 0
Identification and Experimental Verification Reveal SLC2A3 Associated With Prognosis and Immune Infiltration in Colon Adenocarcinoma

Mediators Inflamm, 2026

Open Access
Cited by 0
Identify MTDH as a Key Gene of Radio-Resistance in Colorectal Cancer Based on Multi-Omics and Experimental Validation

Oncol Res, 2026

Open Access
Cited by 0
Immune architecture of colorectal cancer brain metastases: spatial TAM heterogeneity and PD-L1 dynamics

Front Immunol, 2026

Open Access
Cited by 0
In vitro and In silico Analysis of SCIN rs376349889 as a Potential Biomarker for Gastric and Colorectal Cancers

Avicenna J Med Biotechnol, 2026

Open Access
Cited by 0
Inhibitory effect of the multi-target TKI, anlotinib, in 5-FU resistant colorectal cancer HCT-8/15 cells: down regulation of drug resistance-associated protein expression

Front Oncol, 2026

Open Access
Cited by 0
Insect Olfactory Receptor-Expressing Sensor Cells for Colorectal Cancer Diagnosis Using Urine Samples

Cancer Med, 2026

Open Access
Cited by 0
Interpretable machine learning models based on CT radiomics for predicting chemoradiotherapy response in rectal cancer

BMC Med Imaging, 2026

Open Access
Cited by 0
Ketamine Induces Apoptosis and Inhibits Proliferation in HT-29 Colorectal Cancer Cells

Biomedicines, 2026

Open Access
Cited by 0
Laparoscopic Sacrectomy as Part of En Bloc Resection for Locally Recurrent Rectal Cancer

Dis Colon Rectum, 2026

Open Access
Cited by 0
Late-Stage Downregulation of miR-138-5p Promotes Colorectal Cancer Progression

Int J Mol Sci, 2026

Open Access
Cited by 0
Liver Transplantation as a Salvage Therapy Option in Colorectal Liver Metastases: Feasibility, Oncologic Outcomes, and Survival After Failure of Conventional Therapy—A Systematic Review and Meta-Analysis

Cancers (Basel), 2026

Open Access
Cited by 0
Machine Learning-Assisted Plasma Metabolomics Identifies a Five-Metabolite Panel for Colorectal Cancer Detection

ACS Omega, 2026

Open Access
Cited by 0
Metal accumulation in paired colon cancer and adjacent tissues and its relationship with genotoxic and epigenetic biomarkers

Front Public Health, 2026

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Cited by 0
Mucinous histology and resistance to immune checkpoint blockade in patients with microsatellite instability-high metastatic colorectal cancer

Oncologist, 2026

Open Access
Cited by 0
Multi-Transcriptomic Analysis Reveals That EREG-Driven TME Crosstalk Defines Anti-EGFR Response in Colorectal Cancer

Cancer Med, 2026

Open Access
Cited by 0
Multimodal foundation models in colorectal cancer: from prediction to trustworthy clinical insight

Brief Bioinform, 2026

Open Access
Cited by 0
Natural Remedies for Gut Health: The Role of Plant Extracts in Combating Inflammatory Bowel Disease and Colon Cancer

Food Sci Nutr, 2026

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Cited by 0
Navigating the Tumor Microenvironment in Colorectal Liver Metastasis: Barriers to Therapy and Emerging Opportunities

Oncol Res, 2026

Open Access
Cited by 0
Optimizing colorectal cancer screening through polygenic risk score-based risk stratification: evidence from a population-based cohort and screening trial

Genome Med, 2026

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Cited by 0
Outcomes of Thoracic Surgical Oncology Group 103: Multimodality management in risk-stratified patients with lung-limited metastatic colorectal cancer

JTCVS Open, 2026

Open Access
Cited by 0
Phase separation of β-catenin assembles active loop hubs in colorectal cancer

Genome Biol, 2026

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Cited by 0
Phytochemical Analysis and Anticancer Activity of Salvia chinensis Benth in Colorectal Cancer: An Integrated Transcriptomic and Bioinformatic Study

Pharmaceuticals (Basel), 2026

Open Access
Cited by 0
PRELID1 and VDAC3 Coordinate a Senescence-Like State in Germinal Center B Cells to Promote IL-7–Driven Antitumor Immunity in Colorectal Cancer

Adv Sci (Weinh), 2026

Open Access
Cited by 0
Prevalence and determinants of late time to treatment initiation among colorectal cancer patients in the Amhara Region, Ethiopia

Pan Afr Med J, 2026

Open Access
Cited by 0
Prognostic Power of Ensemble Learning in Colorectal Cancer with Peritoneal Metastasis: A Multi-Institutional Analysis

Bioengineering (Basel), 2026

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Cited by 0
Prognostic significance of integrating pretreatment biopsy-derived Immunoscore and Pan-Immune-Inflammation value in locally advanced rectal cancer after neoadjuvant chemoradiotherapy

Clin Transl Radiat Oncol, 2026

Open Access
Cited by 0
Protective Effects of Plant-Based Diets Against Colorectal Carcinogenesis via Modulation of Key Cellular and Molecular Mechanisms: A Comprehensive Review of Evidence

Curr Oncol, 2026

Open Access
Cited by 0
Proteomic remodeling during tumor cell-induced platelet aggregation unveils metastatic drivers in colorectal cancer

Cancer Cell Int, 2026

Open Access
Cited by 0
Quantitative parameters of dual-layer spectral CT for differentiating metastatic and non-metastatic lymph nodes in colorectal cancer

Cancer Imaging, 2026

Open Access
Cited by 0
Reducing endoscopic procedure backlog by improving efficiency: a predictive model and machine learning-based scheduling approach

J Can Assoc Gastroenterol, 2026

Open Access
Cited by 0
Research progress on early diagnostic biomarkers and liquid biopsy technologies for colorectal cancer: a comprehensive review

Front Oncol, 2025

Open Access
Cited by 0
Research trends of tumor-associated macrophages in colorectal cancer: a bibliometric analysis

Int J Surg, 2026

Open Access
Cited by 0
Resiquimod-loaded MOF525 enables synergistic photodynamic therapy and immunotherapy for colorectal cancer

Nano Converg, 2026

Open Access
Cited by 0
Risk Factors for Severe Postoperative Complications After Laparoscopic Colorectal Cancer Surgery in Octogenarians: A Retrospective Cohort Study

Clin Interv Aging, 2026

Open Access
Cited by 0
Risk of colorectal cancer by socioeconomic position and history of mental illness – a national nested case-control study

BMC Cancer, 2026

Open Access
Cited by 0
Risk-Adapted Selective Elective Nodal Irradiation in the Total Neoadjuvant Therapy Era for Rectal Cancer

Medicina (Kaunas), 2026

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Cited by 0
Safety and Efficacy of SOX Therapy After Preoperative Chemoradiotherapy for Advanced Lower Rectal Cancer: A Phase I Study

In Vivo, 2026

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Cited by 0
Simultaneous Establishment of Autologous Colorectal Cancer and Mesothelial Stromal Cell Lines from Malignant Ascites Reveals a Mesothelial-Stromal FGFR3 Axis as a Potential Vulnerability in Peritoneal Metastasis

Cancer Med, 2026

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Cited by 0
Single-cell analysis identified a recurrent malignant-associated transcriptional state in colorectal cancer

Cancer Sci, 2026

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Cited by 0
Single-cell mapping of tumor-driven macrophage reprogramming via ETV4-MC1R underlies immunotherapy resistance in colorectal cancer

Int J Surg, 2026

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Cited by 0
Skeletal Muscle Gauge and Complementary Pan-Immune-Inflammation Value for Risk Stratification of 30-Day Major Complications After Colorectal Cancer Surgery

Biomedicines, 2026

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Cited by 0
Spatial Dynamics Links PD-L1 and Tumor-Associated Macrophage-Enriched Niches to Immune and Mesenchymal States in Microsatellite-Stable Colorectal Cancer

Cancers (Basel), 2026

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Cited by 0
Stent or stoma as a bridge to surgery in patients with acute malignant colorectal obstruction: a comparison of oncologic long-term results

Front Oncol, 2026

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Cited by 0
Symmetry-guided explainable deep learning for colon cancer diagnosis: model benchmarking, cross-validation, statistical analysis, and explainability via ablation studies

Front Artif Intell, 2026

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Cited by 0
Targeting USP14 enhances immunotherapy response by reprogramming tumor-associated macrophages in colon cancer

iScience, 2026

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Cited by 0
The effect of immunonutrition on postoperative ileus following colorectal cancer surgery: a systematic review and meta-analysis of randomized controlled trials

Front Nutr, 2026

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Cited by 0
The interplay between Peptostreptococcus and Fusobacterium as novel signatures in colorectal cancer recurrence

Microbiome, 2026

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Cited by 0
The MIF-CD74 axis drives colorectal cancer via glycolytic reprogramming and is targeted by a novel small-molecule inhibitor

Cell Oncol (Dordr), 2026

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Cited by 0
The prognostic value of immunoscore in colorectal cancer liver metastases: a meta-analysis reveals the superiority of metastatic over primary tumor profiling

BMC Cancer, 2026

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Cited by 0
The Tumour Immune Microenvironment as a Predictor of the Response to Neoadjuvant Therapy in Rectal Cancer

Cancers (Basel), 2026

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Cited by 0
Transcriptomic and single-cell analyses reveal the prognostic value of ETV4 and its role in shaping the immune landscape of colorectal cancer

Transl Oncol, 2026

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Cited by 0
Tumor Budding in Colorectal Carcinoma—From Incidental Observation to Prognostic Marker: Lessons Learned from Colorectal Cancer Assessment

Medicina (Kaunas), 2026

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Cited by 0
TWIST1 mediated transcriptional activation of SPON2 drives colorectal cancer peritoneal metastasis through stromal cell signaling network

Oncogene, 2026

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Cited by 0
TYRO3, AXL, MERTK and Their Ligands in Brain Metastases From Colorectal Cancers

Cancer Med, 2026

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Cited by 0
Upregulation of Sox2 Following Saracatinib Treatment Contributes to a Resistant Phenotype in Colorectal Cancer Cells under Growth Factor-Supplemented Conditions

Oncol Res, 2026

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Cited by 0
Variant-to-Biomarker Integration and Mechanistic Validation Identify CES1 as a Copy Number-Linked Predictor of Radiotherapy Response in Rectal Cancer

Hum Mutat, 2026

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Cited by 0
Zebularine Boosts Imatinib Efficacy in Cells of Colorectal Cancer via Wnt-survivin-P-glycoprotein pathway.

J Biochem Mol Toxicol, 2026

Open Access